When designing a protocol, efforts must be deployed to monitor, limit or avoid any animal suffering, and if suffering is unavoidable, humane endpoints should be monitored. This is important for ethical, scientific, and legal reasons. DECRO telemetric jacket, which is completely non-invasive and non-restraining, offers the possibility to monitor humane endpoints based on the surveillance of essential cardiorespiratory endpoints.
In addition, this solution can be used in integrative physiology investigations as well as in universities physiology training programs.
Physiopathology or longitudinal studies
There is an increased demand for animal models addressing cardiovascular, pulmonary or neurologic diseases, but the creation of chronic disease conditions requires continuous welfare assessment.
Some animal models involving rats have the potential to cause pain, suffering, distress and lasting harm to the animals involved. Such models are typically classified in legislation (e.g. the European Directive on the protection of animals used for scientific purposes (2010/63/EU)) as moderate or severe procedures.
DECRO telemetric jacket is a valuable and relevant tool to monitor cardiorespiratory parameters when developing such models (i;e. arrhythmias, coronary vascular occlusion, ischemic stroke, pulmonary fibrosis, BPCO…..). Such external telemetric solution can also be used for longitudinal studies where the subjects are studied on successive experiment days, or when subjects are particularly fragile and cannot tolerate surgery or anesthesia.
Early safety pharmacology
Cardiac and respiratory unexpected effects are considered frequent during drug safety testing and remain a major attrition cause.
Cardiovascular monitoring methods using telemetry have become an important component in preclinical safety assessments over the last decade, providing pharmacologists a valuable tool to evaluate drug safety. Implanted telemetry is widely employed to monitor cardiovascular parameters in awake, and freely moving laboratory animals. However, its use has many constraints and involves a lot of scheduling and organization resources.
To evaluate the respiratory effects, pharmacologists commonly use a plethysmograph (whole body or other types), which again has to be well scheduled in the plan.
With DECRO jacketed telemetry, you would be able to optimize your experimental plan by testing, easily and rapidly, your drug candidate on cardiorespiratory physiological parameters, early in your development process. This technology could help you shorten your decision process.