ALL-IN-ONE MONITORING

What does all-in-one monitoring mean?

This means you have access to the combined monitoring of 2 essential physiological functions, coupled with the activity level of your animals, with one single system.
 

The simultaneous recording of these 3 biosignals (cardiac, respiratory and activity) in the same animal during an experiment provides useful information in order to finely interpret heart and respiratory rates changes.

Due to the close relation between activity and cardiorespiratory system, any increase or decrease in the activity level of your animal will have direct effect on heart and respiratory rates.

Respiratory

  • Respiratory Cycle Time
  • Respiratory rate (bpm)
  • Tidal volume
  • Inspiration – Expiration time
  • Minute Volume

Cardiac

  • R peaks detection
  • R-R intervals (mS)
  • Heart Rate (bpm)

Activity 

  • Movements intensity (mG)

Example of a all-in-one monitoring view on an animal at rest

The figure above displays in an all-in-one monitoring view, the three biosignals recorded simultaneously on a rat. From top to bottom, raw ECG data (lead II configuration ECG) with calculated heart rate, respiratory signals with calculated respiratory rate and activity level are recorded during a resting phase from an adult Sprague Dawley male rat, dressed with DECRO jacket.

Relation between activity and heart/respiratory rate measured using DECRO jacket

This example shows how heart and respiratory rate increase with activity level. At rest, heart and respiratory rates are approximately 330 beat/min and 75 breath/min, respectively. As activity level increases, heart and respiratory rates increase up to 460 beat/min and 150 breath/min, respectively.

It is simple, with the DECRO solution, to qualify the exploitable study periods and to get answers about artefacts observed in respiratory or cardiac signals.

Case studies

Below two cases are presented where changes in activity were associated with changes in respiratory and heart rates.

CASE 1: Inactive and awake rat

Respiratory and heart rates are correlated with activity level. When the activity decreases, the heart rate follows the same pattern and the respiratory rate to a lesser extent. Note that an alternation between respiratory cycles and sniffing are present in the raw signal (below the graphs) providing evidence that the rat is awake while at rest.

CASE 2: Inactive and asleep rat

Heart rate but not respiratory rate is correlated with activity level. When the activity decreases, the heart rate follows the same pattern but the respiratory rate follows the opposite one. Based on the observation that the raw signal (below the graphs) is devoid of sniffing and only respiratory cycles are homogeneously present, the increase in respiratory rate can be explained by the fact that the rat is sleeping. Indeed, without the heart rate and activity level, interpretation of respiratory results would have been erroneous.

Both cases show that the all-in-one solution providing simultaneous recording of the 3 biosignals is very helpful to researchers in their results analysis and interpretation.

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